Prolonged Postnatal Hypoxia Impairs Lung Development and Causes Severe Pulmonary Hypertension in Mice

Background In children born at high altitude, lung development is affected by hypoxia, which can lead to pulmonary hypertension and right ventricular failure. Animal models of postnatal, transient, hypoxia failed to reproduce these conditions seen in children living at high altitude. The aim of this...

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Hlavní autoři:	Luca Zazzeron, Kakeru Shimoda, Paul Lichtenegger, Elizabeth Moore, Helena Tattersfield, Alexandra K. Marenco, Jiayi Kang, Haobo Li, Eizo Marutani, Donald B. Bloch, Fumito Ichinose
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Wiley 2025-10-01
Edice:	Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Témata:	bronchopulmonary dysplasia hypoxia pediatric pulmonary hypertension pulmonary hypertension right ventricular dysfunction
On-line přístup:	https://www.ahajournals.org/doi/10.1161/JAHA.125.042608
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