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The rs7799039 variant in the leptin gene promoter drives insulin resistance through reduced serum leptin levels

BackgroundThe associations between the rs7799039 variant in the promoter region of the leptin gene (LEP) and the rs1137100, rs1137101, and rs1805094 variants in the exons of the leptin receptor gene (LEPR) with leptin levels and glucose-lipid metabolism markers have been examined across various popu...

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Principais autores: Yongyan Song, Youjin Zhang, Xinyu Liu, Wang Gong, Yinquan Ai, Binger Shen, Jing Li, Chuan He
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2025-10-01
coleção:Frontiers in Endocrinology
Assuntos:
leptin
rs7799039
rs1137101
rs1805094
glucose-lipid metabolism
variant
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fendo.2025.1589575/full
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