Ten years of progress and promise of induced pluripotent stem cells: historical origins, characteristics, mechanisms, limitations, and potential applications

The discovery of induced pluripotent stem cells (iPSCs) by Shinya Yamanaka in 2006 was heralded as a major breakthrough of the decade in stem cell research. The ability to reprogram human somatic cells to a pluripotent embryonic stem cell-like state through the ectopic expression of a combination of...

Ausführliche Beschreibung

Bibliografische Detailangaben

Hauptverfasser:	Adekunle Ebenezer Omole, Adegbenro Omotuyi John Fakoya
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	PeerJ Inc. 2018-05-01
Schriftenreihe:	PeerJ
Schlagworte:	Induced pluripotent stem cells Reprogramming Reprogramming factors Embryonic stem cells Gene editing technology CRISPR
Online-Zugang:	https://peerj.com/articles/4370.pdf
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