Demethylation-primed tandem CD19/CD20 CAR T cells in relapsed/refractory B-cell lymphoma: a phase I/II trial

Abstract Despite the success of CAR T therapy in non-Hodgkin lymphoma (NHL), recurrence remains challenging. Previously, we showed that ex vivo priming with decitabine (DAC) enhances CAR T persistence and efficacy. Here, we report on an open-label non-randomised phase I/II trial (NCT04697940) evalua...

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Auteurs principaux:	Chunmeng Wang, Yelei Guo, Fuxin Han, Yipeng Zhang, Chun Liu, Zhiqiang Wu, Chuan Tong, Qingming Yang, Yuting Lu, Yadi Zhong, Jinhong Shi, Jianshu Wei, Yajing Zhang, Yang Liu, Yao Wang, Weidong Han
Format:	Artigo
Langue:	Inglês
Publié:	Nature Portfolio 2026-04-01
Collection:	Nature Communications
Accès en ligne:	https://doi.org/10.1038/s41467-026-72040-4
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