Identification of NOXA as a pivotal regulator of resistance to CAR T-cell therapy in B-cell malignancies

Abstract Despite the remarkable success of chimeric antigen receptor (CAR) T-cell therapy for treating hematologic malignancies, resistance and recurrence still occur, while the markers or mechanisms underlying this resistance remain poorly understood. Here, via an unbiased genome-wide CRISPR/Cas9 s...

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Detalhes bibliográficos

Principais autores:	Xin Yan, Deyun Chen, Yao Wang, Yelei Guo, Chuan Tong, Jianshu Wei, Yajing Zhang, Zhiqiang Wu, Weidong Han
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Nature Publishing Group 2022-04-01
coleção:	Signal Transduction and Targeted Therapy
Acesso em linha:	https://doi.org/10.1038/s41392-022-00915-1
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