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BRD7 Promotes Cell Proliferation and Tumor Growth Through Stabilization of c-Myc in Colorectal Cancer

BRD7 functions as a crucial tumor suppressor in numerous malignancies. However, the effects of BRD7 on colorectal cancer (CRC) progression are still unknown. Here, based on the BRD7 knockout (BRD7–/–) and BRD7flox/flox (BRD7+/+) mouse models constructed in our previous work, we established an azoxym...

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Principais autores: Ran Zhao, Yukun Liu, Chunchun Wu, Mengna Li, Yanmei Wei, Weihong Niu, Jing Yang, Songqing Fan, Yong Xie, Hui Li, Wei Wang, Zhaoyang Zeng, Wei Xiong, Xiaoling Li, Guiyuan Li, Ming Zhou
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2021-05-01
Serier:Frontiers in Cell and Developmental Biology
Fag:
BRD7
oncogene
c-Myc
deubiquitination
colorectal cancer
Online adgang:https://www.frontiersin.org/articles/10.3389/fcell.2021.659392/full
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