Metabolic reprogramming during human neuron differentiation indicates glutaminase as a key determinant in Fragile X syndrome

Summary: Metabolic homeostasis gone awry is a contributor to, if not an underlying cause of, several neurologic disorders. Fragile X syndrome (FXS) is a neurodevelopmental disorder caused by a trinucleotide repeat expansion in FMR1 and consequent loss of the encoded protein FMRP, which results in do...

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Autori principali:	Sneha Shah, Daniel Barnes, Botao Liu, Tenzin Tseyang, Thang Do, Jodi L. Bubenik, Suna Jung, Mina N. Anadolu, Maria P. Ivshina, Verónica Martínez-Cerdeño, Elizabeth Berry-Kravis, Maurice S. Swanson, Jessica B. Spinelli, Joel D. Richter
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Elsevier 2026-01-01
Serie:	Cell Reports
Soggetti:	CP: neuroscience CP: metabolism
Accesso online:	http://www.sciencedirect.com/science/article/pii/S2211124725016298
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