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Concurrent epigenetic silencing of wnt/β-catenin pathway inhibitor genes in B cell chronic lymphocytic leukaemia

<p>Abstract</p> <p>Background</p> <p>The Wnt/β-catenin signalling is aberrantly activated in primary B cell chronic lymphocytic leukaemia (CLL). Epigenetic silencing of pathway inhibitor genes may be a mechanism for its activation. In this study, we investigated systematically and quantitatively the...

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Principais autores: Moskalev Evgeny A, Luckert Katrin, Vorobjev Ivan A, Mastitsky Sergey E, Gladkikh Aleena A, Stephan Achim, Schrenk Marita, Kaplanov Kamil D, Kalashnikova Olga B, Pötz Oliver, Joos Thomas O, Hoheisel Jörg D
Formato: Artigo
Idioma:Inglês
Publicado: BMC 2012-06-01
Series:BMC Cancer
Assuntos:
B cell chronic lymphocytic leukaemia
Wnt/β-catenin pathway
Inhibitor genes
DNA hypermethylation
Epigenetic silencing
β-catenin
Acceso en liña:http://www.biomedcentral.com/1471-2407/12/213
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