Targeting Wnt/β-catenin signaling enhances the efficacy of anti-CD38 immunotherapy in multiple myeloma

Background: Previous studies have shown that the Wnt/β-catenin signaling pathway is aberrantly activated in multiple myeloma (MM) and regulates the growth of MM cells, while recent studies reported crosstalk between Wnt and STAT3 signaling in various non-MM systems. In addition, it has been shown th...

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Main Authors: Heng Li, Yunguang Chen, Michaela Gregorova, Tingting Yang, Xiayi Zhang, Xiaoyu Yu, Zhen Wang, Haiying Hua, Long Ye, Xiaowei Qi, Marcel Spaargaren, Steven T. Pals, Zemin Ren
Format: Artigo
Jezik:Inglês
Izdano: Elsevier 2025-12-01
Serija:Neoplasia: An International Journal for Oncology Research
Teme:
Multiple myeloma
Wnt/β-catenin
STAT3 pathway
CD38
Daratumumab
Online dostop:http://www.sciencedirect.com/science/article/pii/S1476558625001228
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