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Residue-Specific Incorporation of the Non-Canonical Amino Acid Norleucine Improves Lipase Activity on Synthetic Polyesters

Environmentally friendly functionalization and recycling processes for synthetic polymers have recently gained momentum, and enzymes play a central role in these procedures. However, natural enzymes must be engineered to accept synthetic polymers as substrates. To enhance the activity on synthetic p...

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Principais autores: Karolina Haernvall, Patrik Fladischer, Heidemarie Schoeffmann, Sabine Zitzenbacher, Tea Pavkov-Keller, Karl Gruber, Michael Schick, Motonori Yamamoto, Andreas Kuenkel, Doris Ribitsch, Georg M. Guebitz, Birgit Wiltschi
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2022-01-01
Serier:Frontiers in Bioengineering and Biotechnology
Fag:
polyester modification
enzyme hydrolysis
genetic code engineering
lipase
Thermoanaerobacter thermohydrosulfuricus
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Online adgang:https://www.frontiersin.org/articles/10.3389/fbioe.2022.769830/full
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