Amphiregulin-producing TH2 cells facilitate esophageal fibrosis of eosinophilic esophagitis

Background: Massive eosinophil infiltration into the esophagus is associated with subepithelial fibrosis and esophageal stricture in patients with eosinophilic esophagitis (EoE). However, the pathogenesis of esophageal fibrosis remains unclear. Objective: We sought to elucidate the cellular and mole...

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Auteurs principaux:	Tatsuya Kaneko, MD, PhD, Chiaki Iwamura, PhD, Masahiro Kiuchi, VMD, PhD, Akane Kurosugi, MD, PhD, Miki Onoue, MD, PhD, Tomoaki Matsumura, MD, PhD, Tetsuhiro Chiba, MD, PhD, Toshinori Nakayama, MD, PhD, Naoya Kato, MD, PhD, Kiyoshi Hirahara, MD, PhD
Format:	Artigo
Langue:	Inglês
Publié:	Elsevier 2024-08-01
Collection:	Journal of Allergy and Clinical Immunology: Global
Sujets:	Eosinophilic esophagitis ST2+ TH2 cells amphiregulin fibroblasts esophageal fibrosis single-cell RNA sequencing
Accès en ligne:	http://www.sciencedirect.com/science/article/pii/S2772829324000833
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