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Amphiregulin-producing TH2 cells facilitate esophageal fibrosis of eosinophilic esophagitis

Background: Massive eosinophil infiltration into the esophagus is associated with subepithelial fibrosis and esophageal stricture in patients with eosinophilic esophagitis (EoE). However, the pathogenesis of esophageal fibrosis remains unclear. Objective: We sought to elucidate the cellular and mole...

Deskribapen osoa

Gorde:
Egile Nagusiak: Tatsuya Kaneko, MD, PhD, Chiaki Iwamura, PhD, Masahiro Kiuchi, VMD, PhD, Akane Kurosugi, MD, PhD, Miki Onoue, MD, PhD, Tomoaki Matsumura, MD, PhD, Tetsuhiro Chiba, MD, PhD, Toshinori Nakayama, MD, PhD, Naoya Kato, MD, PhD, Kiyoshi Hirahara, MD, PhD
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Elsevier 2024-08-01
Saila:Journal of Allergy and Clinical Immunology: Global
Gaiak:
Eosinophilic esophagitis
ST2+ TH2 cells
amphiregulin
fibroblasts
esophageal fibrosis
single-cell RNA sequencing
Sarrera elektronikoa:http://www.sciencedirect.com/science/article/pii/S2772829324000833
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