Neck linker docking is critical for Kinesin-1 force generation in cells but at a cost to motor speed and processivity

Kinesin force generation involves ATP-induced docking of the neck linker (NL) along the motor core. However, the roles of the proposed steps of NL docking, cover-neck bundle (CNB) and asparagine latch (N-latch) formation, during force generation are unclear. Furthermore, the necessity of NL docking...

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Príomhchruthaitheoirí:	Breane G Budaitis, Shashank Jariwala, Dana N Reinemann, Kristin I Schimert, Guido Scarabelli, Barry J Grant, David Sept, Matthew J Lang, Kristen J Verhey
Formáid:	Artigo
Teanga:	Inglês
Foilsithe / Cruthaithe:	eLife Sciences Publications Ltd 2019-05-01
Sraith:	eLife
Ábhair:	microtubule kinesin force molecular motor neck linker cover-neck bundle
Rochtain ar líne:	https://elifesciences.org/articles/44146
Clibeanna:	Cuir clib leis Níl clibeanna ann, Bí ar an gcéad duine le clib a chur leis an taifead seo!

Neck linker docking is critical for Kinesin-1 force generation in cells but at a cost to motor speed and processivity

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