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Neck linker docking is critical for Kinesin-1 force generation in cells but at a cost to motor speed and processivity

Kinesin force generation involves ATP-induced docking of the neck linker (NL) along the motor core. However, the roles of the proposed steps of NL docking, cover-neck bundle (CNB) and asparagine latch (N-latch) formation, during force generation are unclear. Furthermore, the necessity of NL docking...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Breane G Budaitis, Shashank Jariwala, Dana N Reinemann, Kristin I Schimert, Guido Scarabelli, Barry J Grant, David Sept, Matthew J Lang, Kristen J Verhey
Format: Artigo
Sprache:Inglês
Veröffentlicht: eLife Sciences Publications Ltd 2019-05-01
Schriftenreihe:eLife
Schlagworte:
microtubule
kinesin
force
molecular motor
neck linker
cover-neck bundle
Online-Zugang:https://elifesciences.org/articles/44146
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