Impact of Different Surfactants on Oral Bioavailability of Paclitaxel/HPMC-AS Amorphous Solid Dispersion

<b>Objectives:</b> Surfactants are commonly incorporated into amorphous solid dispersions (ASDs) to improve manufacturing and enhance the dissolution of poorly water-soluble drugs. However, their impact on in vitro dissolution, in vivo bioavailability, and in vitro-in vivo correlation (IVIVC) remain...

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Главные авторы:	Chenzhao Zhang, Siyi Mao, Jinhua Yuan, Xiuzhen Ma, Aiya Xing, Xiaoling Liu, Yuejie Chen
Формат:	Artigo
Язык:	Inglês
Опубликовано:	MDPI AG 2025-11-01
Серии:	Pharmaceutics
Предметы:	paclitaxel (PTX) poorly water-soluble drug oral bioavailability amorphous solid dispersion (ASD) surfactant
Online-ссылка:	https://www.mdpi.com/1999-4923/17/11/1487
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