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Impact of Different Surfactants on Oral Bioavailability of Paclitaxel/HPMC-AS Amorphous Solid Dispersion

<b>Objectives:</b> Surfactants are commonly incorporated into amorphous solid dispersions (ASDs) to improve manufacturing and enhance the dissolution of poorly water-soluble drugs. However, their impact on in vitro dissolution, in vivo bioavailability, and in vitro-in vivo correlation (IVIVC) remain...

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Main Authors: Chenzhao Zhang, Siyi Mao, Jinhua Yuan, Xiuzhen Ma, Aiya Xing, Xiaoling Liu, Yuejie Chen
Format: Artigo
Language:Inglês
Published: MDPI AG 2025-11-01
Series:Pharmaceutics
Subjects:
paclitaxel (PTX)
poorly water-soluble drug
oral bioavailability
amorphous solid dispersion (ASD)
surfactant
Online Access:https://www.mdpi.com/1999-4923/17/11/1487
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