Redox homeostasis and inflammation in fibroblasts of patients with Friedreich Ataxia: a possible cross talk

Redox homeostasis is impaired in Friedreich’s Ataxia (FRDA), a neurodegenerative disease caused by the decreased expression of the mitochondrial protein frataxin. Nrf2, the master regulator of tissue redox balance, is defective in the disease, driving cells to ferroptosis. Neuro-inflammation is rece...

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Principais autores:	Andrea Quatrana, Sara Petrillo, Caterina Torda, Eleonora De Santis, Enrico Bertini, Fiorella Piemonte
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2025-04-01
coleção:	Frontiers in Molecular Neuroscience
Assuntos:	Freidreich Ataxia Nrf2 NF-kB TLR4 GLRX1 Trx1
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fnmol.2025.1571402/full
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