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Redox homeostasis and inflammation in fibroblasts of patients with Friedreich Ataxia: a possible cross talk

Redox homeostasis is impaired in Friedreich’s Ataxia (FRDA), a neurodegenerative disease caused by the decreased expression of the mitochondrial protein frataxin. Nrf2, the master regulator of tissue redox balance, is defective in the disease, driving cells to ferroptosis. Neuro-inflammation is rece...

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Main Authors: Andrea Quatrana, Sara Petrillo, Caterina Torda, Eleonora De Santis, Enrico Bertini, Fiorella Piemonte
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2025-04-01
Series:Frontiers in Molecular Neuroscience
Subjects:
Freidreich Ataxia
Nrf2
NF-kB
TLR4
GLRX1
Trx1
Online Access:https://www.frontiersin.org/articles/10.3389/fnmol.2025.1571402/full
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