Structural Basis for Targeting the Bifunctional Enzyme ArnA
Polymyxin antibiotics are often the last line of defense against multidrug-resistant Gram-negative pathogens. A key resistance mechanism involves the addition of 4-amino-4-deoxy-L-arabinose (L-Ara4N) to lipid A, mediated by the bifunctional enzyme ArnA. However, the evolutionary rationale and struct...
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| Principais autores: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
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MDPI AG
2025-11-01
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| coleção: | Biomolecules |
| Assuntos: | |
| Acesso em linha: | https://www.mdpi.com/2218-273X/15/11/1594 |
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