Structural Basis for Targeting the Bifunctional Enzyme ArnA

Polymyxin antibiotics are often the last line of defense against multidrug-resistant Gram-negative pathogens. A key resistance mechanism involves the addition of 4-amino-4-deoxy-L-arabinose (L-Ara4N) to lipid A, mediated by the bifunctional enzyme ArnA. However, the evolutionary rationale and struct...

תיאור מלא

מידע ביבליוגרפי

Principais autores:	Xinyu Liu, Ruochen Yang, Libang Ren, Tong Li, Yanrong Li, Zhihua Yan, Yanrong Gao, Mingqi Yang, Jiazhi Li
פורמט:	Artigo
שפה:	Inglês
יצא לאור:	MDPI AG 2025-11-01
סדרה:	Biomolecules
נושאים:	ArnA L-Ara4N modification structure peptide inhibitor
גישה מקוונת:	https://www.mdpi.com/2218-273X/15/11/1594
תגים:	הוספת תג אין תגיות, היה/י הראשונ/ה לתייג את הרשומה!