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Anti-<i>Trypanosoma cruzi</i> Activity, Mutagenicity, Hepatocytotoxicity and Nitroreductase Enzyme Evaluation of 3-Nitrotriazole, 2-Nitroimidazole and Triazole Derivatives

Chagas disease (CD), which is caused by <i>Trypanosoma cruzi</i> and was discovered more than 100 years ago, remains the leading cause of death from parasitic diseases in the Americas. As a curative treatment is only available for the acute phase of CD, the search for new therapeutic options is urge...

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Principais autores: Cheyene Almeida Celestino Menozzi, Rodolfo Rodrigo Florido França, Pedro Henrique Luccas, Mayara dos Santos Baptista, Tácio Vinício Amorim Fernandes, Lucas Villas Bôas Hoelz, Policarpo Ademar Sales Junior, Silvane Maria Fonseca Murta, Alvaro Romanha, Bárbara Verena Dias Galvão, Marcela de Oliveira Macedo, Alana da Cunha Goldstein, Carlos Fernando Araujo-Lima, Israel Felzenszwalb, Maria Cristina Nonato, Frederico Silva Castelo-Branco, Nubia Boechat
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2023-11-01
Serier:Molecules
Fag:
Chagas disease
<i>Trypanosoma cruzi</i>
azole
nitroreductase
CYP51
triazole
Online adgang:https://www.mdpi.com/1420-3049/28/22/7461
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