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Genetic diversity in the metronidazole metabolism genes nitroreductases and pyruvate ferredoxin oxidoreductases in susceptible and refractory clinical samples of Giardia lamblia

The effectiveness of metronidazole against the tetraploid intestinal parasite Giardia lamblia is dependent on its activation/inactivation within the cytoplasm. There are several activating enzymes, including pyruvate ferredoxin reductase (PFOR) and nitroreductase (NR) 1 which metabolize metronidazol...

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Principais autores: Christina S. Saghaug, Astrid L. Gamlem, Kirsti B. Hauge, Juha Vahokoski, Christian Klotz, Toni Aebischer, Nina Langeland, Kurt Hanevik
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2023-04-01
Serier:International Journal for Parasitology: Drugs and Drug Resistance
Fag:
Nitroreductase
Pyruvate ferredoxin oxidoreductase
Metronidazole
Genetic diversity
Allele
Resistance
Online adgang:http://www.sciencedirect.com/science/article/pii/S2211320722000367
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