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Genetic co-regulation of neopterin and Parkinson’s disease

Abstract Neopterin is a pro-inflammatory molecule upregulated in several diseases; however, its role in pathophysiology is unclear and its genetic regulation is unexplored. We observed that neopterin levels increase during senescence (P-value = 1.88×10 -13 , beta = 0.96) and positively correlate wit...

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Autori principali: Valeria Orrù, Michele Marongiu, Maristella Steri, Mara Marongiu, Carlo Sidore, Valentina Serra, Mauro Pala, Stefania Olla, Noemi Toggia, Matteo Floris, Monia Lobina, Maria Grazia Piras, Antonella Mulas, Andrea Maschio, Mariano Dei, Marina Parolini, Cinzia Dellanoce, Alessandro Delitala, 23andMe Research Team, David Schlessinger, Jonica Campolo, Marcella Devoto, Magdalena Zoledziewska, Francesco Cucca, Edoardo Fiorillo
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Portfolio 2026-02-01
Serie:npj Parkinson's Disease
Accesso online:https://doi.org/10.1038/s41531-026-01279-x
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