DrugBERT: a BERT-based approach integrating LDA topic embedding and efficacy-aware mechanism for predicting anti-tumor drug efficacy

Abstract Background Due to the complexity of tumor genetic heterogeneity, personalized medicine has progressively emerged as the central focus of cancer research. However, how to accurately predict the drug response of patients before receiving treatment is the critical challenge to the development...

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Autores principales:	Weiwei Zhu, Xiaodong Jiang, Lei Zhang, Peng Zhou, Xinping Xie, Hongqiang Wang
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	BMC 2025-08-01
Colección:	Journal of Translational Medicine
Materias:	Drug efficacy prediction LDA topic embedding BERT Self-attention mechanism Clinical text data
Acceso en línea:	https://doi.org/10.1186/s12967-025-06795-7
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