DrugBERT: a BERT-based approach integrating LDA topic embedding and efficacy-aware mechanism for predicting anti-tumor drug efficacy

Abstract Background Due to the complexity of tumor genetic heterogeneity, personalized medicine has progressively emerged as the central focus of cancer research. However, how to accurately predict the drug response of patients before receiving treatment is the critical challenge to the development...

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Detalhes bibliográficos

Principais autores:	Weiwei Zhu, Xiaodong Jiang, Lei Zhang, Peng Zhou, Xinping Xie, Hongqiang Wang
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2025-08-01
coleção:	Journal of Translational Medicine
Assuntos:	Drug efficacy prediction LDA topic embedding BERT Self-attention mechanism Clinical text data
Acesso em linha:	https://doi.org/10.1186/s12967-025-06795-7
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