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Combinational Inhibition of MEK and AKT Synergistically Induces Melanoma Stem Cell Apoptosis and Blocks NRAS Tumor Growth

Malignant melanoma is a lethal skin cancer containing melanoma-initiating cells (MICs), implicated in tumorigenesis, invasion, and drug resistance, and characterized by an elevated expression of stem cell markers, including CD133. siRNA knockdown of CD133 has been previously shown to enhance apoptos...

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Autori principali: Ryyan Alobaidi, Nusrat Islam, Toni Olkey, Yogameenakshi Haribabu, Mathew Shamo, Peter Sykora, Cynthia M. Simbulan-Rosenthal, Dean S. Rosenthal
Natura: Artigo
Lingua:Inglês
Pubblicazione: MDPI AG 2025-02-01
Serie:Cells
Soggetti:
NRAS
drug resistance
capivasertib
trametinib
xenograft
CRISPR-Cas9
Accesso online:https://www.mdpi.com/2073-4409/14/4/248
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