Modulation of Toll-like receptor 1 intracellular domain structure and activity by Zn2+ ions
Lushpa et al report the structure and dynamics of the TLR1 toll-interleukin like (TIR) cytoplasmic domain in both crystal and solution. They demonstrate that the TLR1 TIR domain is capable of specific binding of Zn with nanomolar affinity, which appears to be critical for receptor activation, and pr...
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| Asıl Yazarlar: | , , , , , , , , , , , , |
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| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
Nature Portfolio
2021-08-01
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| Seri Bilgileri: | Communications Biology |
| Online Erişim: | https://doi.org/10.1038/s42003-021-02532-0 |
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