Spatial structure of TLR4 transmembrane domain in bicelles provides the insight into the receptor activation mechanism
Abstract Toll-like receptors (TLRs) play a key role in the innate and adaptive immune systems. While a lot of structural data is available for the extracellular and cytoplasmic domains of TLRs, and a model of the dimeric full-length TLR3 receptor in the active state was build, the conformation of th...
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| Hlavní autoři: | , , , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
Nature Portfolio
2017-07-01
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| Edice: | Scientific Reports |
| On-line přístup: | https://doi.org/10.1038/s41598-017-07250-4 |
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