Mitochondrial (mt)DNA–cyclic GMP–AMP synthase (cGAS)–stimulator of interferon genes (STING) signaling promotes pyroptosis of macrophages via interferon regulatory factor (IRF)7/IRF3 activation to aggravate lung injury during severe acute pancreatitis

Abstract Background Macrophage proinflammatory activation contributes to the pathology of severe acute pancreatitis (SAP) and, simultaneously, macrophage functional changes, and increased pyroptosis/necrosis can further exacerbate the cellular immune suppression during the process of SAP, where cycl...

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Principais autores:	Yiqiu Peng, Yuxi Yang, Yingying Li, Tingjuan Shi, Ning Xu, Ruixia Liu, Yingyi Luan, Yongming Yao, Chenghong Yin
Format:	Artigo
Jezik:	Inglês
Izdano:	BMC 2024-04-01
Serija:	Cellular & Molecular Biology Letters
Teme:	Severe acute pancreatitis Macrophage NLRP3 Pyroptosis IRF7 IRF3
Online dostop:	https://doi.org/10.1186/s11658-024-00575-9
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