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Xuebijing enhances antitumor efficacy of anti-CD19 CAR-T cells

Objective: To investigate the effects and mechanisms of Xuebijing injection (XBJ) on Chimeric antigen receptor-T (CAR-T) cell function and its therapeutic potential against CAR-T therapy-associated cytokine storms (CRS). Methods: Anti-CD19 CAR-T cells were established based on FMC63 antibodies. Diff...

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Principais autores: Jingjing Zhu, Jing Zhang, Ping Wang, Xiuying Liu, Jingjing Liu, Yichao Feng, Mary Yue Jiang, Zhiqiao Feng, Xiaoqing Yao, Jianxun Wang
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2024-10-01
coleção:Journal of Traditional Chinese Medical Sciences
Assuntos:
Xuebijing
Chimeric antigen receptor-T
Inflammatory cytokines
Macrophage
Cytokine release syndrome
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S2095754824000656
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