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CD19 CAR T cells for B cell malignancies: a systematic review and meta-analysis focused on clinical impacts of CAR structural domains, manufacturing conditions, cellular product, doses, patient’s age, and tumor types

Abstract CD19-targeted chimeric antigen receptors (CAR) T cells are one of the most remarkable cellular therapies for managing B cell malignancies. However, long-term disease-free survival is still a challenge to overcome. Here, we evaluated the influence of different hinge, transmembrane (TM), and...

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Autores principales: Erik Montagna, Najla Santos Pacheco de Campos, Victoria Alves Porto, Giselle Correia Próspero da Silva, Eloah Rabello Suarez
Formato: Artigo
Lenguaje:Inglês
Publicado: BMC 2024-08-01
Colección:BMC Cancer
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Acceso en línea:https://doi.org/10.1186/s12885-024-12651-6
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