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Decline in estimated glomerular filtration rate following substitution of Nevirapine-based regimen with Tenofovir-based regimen in Indonesia

Abstract Background Indonesia started transitioning people living with HIV (PLHIV) from Nevirapine (NVP)-based antiretroviral therapy to tenofovir (TDF)-lamivudine-dolutegravir fixed-dose combination (TLD) in 2023. We aimed to evaluate changes in estimated glomerular filtration rate (eGFR) and predi...

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Autori principali: Evy Yunihastuti, Pringgodigdo Nugroho, Muhammad Yusuf, Salfia Dian Lastari, Fadlika Harinda, Tiara Kumala Putri, Meivina Ramadhani Pane, Metra Adi Pratama, Mira Yulianti, Alvina Widhani, Suzy Maria, Anshari Saifuddin Hasibuan, Maruhum Bonar Hasiholan Marbun, Sukamto Koesnoe, Teguh Harjono Karjadi
Natura: Artigo
Lingua:Inglês
Pubblicazione: BMC 2025-10-01
Serie:BMC Infectious Diseases
Soggetti:
Dolutegravir
Drug substitution
Kidney function
Nevirapine
Tenofovir
ART
Accesso online:https://doi.org/10.1186/s12879-025-11710-y
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