Sphingosine-1-phosphate promotes CD8 T cell exhaustion in breast cancer via exosomal transfer of TGFBR2
Abstract Sphingosine-1-phosphate (S1P) has been implicated in promoting breast cancer progression, but its role in fostering an immunosuppressive microenvironment remains largely unexplored. In our study, co-culturing CD8 T cells with S1P-treated MCF7 cells significantly reduced CD8 T cell prolifera...
Gardado en:
| Principais autores: | , , , , , , , , |
|---|---|
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Nature Publishing Group
2026-03-01
|
| Series: | Cell Death and Disease |
| Acceso en liña: | https://doi.org/10.1038/s41419-026-08523-5 |
| Tags: |
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!
|