Sphingosine-1-phosphate promotes CD8 T cell exhaustion in breast cancer via exosomal transfer of TGFBR2

Abstract Sphingosine-1-phosphate (S1P) has been implicated in promoting breast cancer progression, but its role in fostering an immunosuppressive microenvironment remains largely unexplored. In our study, co-culturing CD8 T cells with S1P-treated MCF7 cells significantly reduced CD8 T cell prolifera...

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Autors principals:	Avinandan Bhoumick, Arnab Ghosh, Arpana Singh, Subhasis Mandal, Tanvi Agarwal, Rima Halder, Biswajit Das, Soma Mukhopadhyay, Prosenjit Sen
Format:	Artigo
Idioma:	Inglês
Publicat:	Nature Publishing Group 2026-03-01
Col·lecció:	Cell Death and Disease
Accés en línia:	https://doi.org/10.1038/s41419-026-08523-5
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