Disrupting stroke-induced GAT-1-syntaxin1A interaction promotes functional recovery after stroke

Summary: Although stroke is a frequent cause of permanent disability, our ability to promote stroke recovery is limited. Here, we design a small-molecule stroke recovery promoting agent that works by dissociating γ-aminobutyric acid (GABA) transporter 1 (GAT-1) from syntaxin1A (Synt1A), a soluble N-...

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Principais autores:	Yu-Hui Lin, Feng Wu, Ting-You Li, Long Lin, Fan Gao, Li-Juan Zhu, Xiu-Mei Xu, Ming-Yu Chen, Ya-Lan Hou, Chang-Jing Zhang, Hai-Yin Wu, Lei Chang, Chun-Xia Luo, Ya-Juan Qin, Dong-Ya Zhu
פורמט:	Artigo
שפה:	Inglês
יצא לאור:	Elsevier 2024-11-01
סדרה:	Cell Reports Medicine
נושאים:	stroke GAT-1 syntaxin1A network plasticity functional recovery
גישה מקוונת:	http://www.sciencedirect.com/science/article/pii/S2666379124005366
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