Effects of cyclosporin on cholesterol 27-hydroxylation and LDL receptor activity in HepG2 cells.
The hypothesis that mitochondrial sterol 27-hydroxylase plays a role in the sterol-mediated down-regulation of LDL receptor activity was evaluated in HepG2 cells. 27-Hydroxycholesterol was found to be more potent at suppressing LDL receptor activity than cholesterol (IC50 values of 8 mu M and 142 mu...
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| Principais autores: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Elsevier
1996-01-01
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| coleção: | Journal of Lipid Research |
| Acesso em linha: | http://www.sciencedirect.com/science/article/pii/S002222752037646X |
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