Effects of cyclosporin on cholesterol 27-hydroxylation and LDL receptor activity in HepG2 cells.
The hypothesis that mitochondrial sterol 27-hydroxylase plays a role in the sterol-mediated down-regulation of LDL receptor activity was evaluated in HepG2 cells. 27-Hydroxycholesterol was found to be more potent at suppressing LDL receptor activity than cholesterol (IC50 values of 8 mu M and 142 mu...
Збережено в:
| Автори: | , , , |
|---|---|
| Формат: | Artigo |
| Мова: | Inglês |
| Опубліковано: |
Elsevier
1996-01-01
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| Серія: | Journal of Lipid Research |
| Онлайн доступ: | http://www.sciencedirect.com/science/article/pii/S002222752037646X |
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