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A Generalized Gene-Regulatory Network Model of Stem Cell Differentiation for Predicting Lineage Specifiers

Identification of cell-fate determinants for directing stem cell differentiation remains a challenge. Moreover, little is known about how cell-fate determinants are regulated in functionally important subnetworks in large gene-regulatory networks (i.e., GRN motifs). Here we propose a model of stem c...

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Autors principals: Satoshi Okawa, Sarah Nicklas, Sascha Zickenrott, Jens C. Schwamborn, Antonio del Sol
Format: Artigo
Idioma:Inglês
Publicat: Elsevier 2016-09-01
Col·lecció:Stem Cell Reports
Accés en línia:http://www.sciencedirect.com/science/article/pii/S2213671116301382
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