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Quinonoid dihydropteridine reductase, a tetrahydrobiopterin-recycling enzyme, contributes to 5-hydroxytryptamine-associated platelet aggregation in mice

Quinonoid dihydropteridine reductase (QDPR) regenerates tetrahydrobiopterin (BH4), which is an essential cofactor for catecholamine and serotonin (5-hydroxytryptamine, 5-HT) biosynthesis. Serotonin is known as an important platelet agonist, but its role under BH4-synthesizing or recycling enzymes de...

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Principais autores: Yui Suganuma, Chiho Sumi-Ichinose, Taiki Kano, Kazuhisa Ikemoto, Taei Matsui, Hiroshi Ichinose, Kazunao Kondo
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2022-11-01
coleção:Journal of Pharmacological Sciences
Assuntos:
Quinonoid dihydropteridine reductase
Tetrahydrobiopterin
Platelet aggregation
Serotonin
Secondary aggregation
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S1347861322000664
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