Quinonoid dihydropteridine reductase, a tetrahydrobiopterin-recycling enzyme, contributes to 5-hydroxytryptamine-associated platelet aggregation in mice

Quinonoid dihydropteridine reductase (QDPR) regenerates tetrahydrobiopterin (BH4), which is an essential cofactor for catecholamine and serotonin (5-hydroxytryptamine, 5-HT) biosynthesis. Serotonin is known as an important platelet agonist, but its role under BH4-synthesizing or recycling enzymes de...

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Autori principali:	Yui Suganuma, Chiho Sumi-Ichinose, Taiki Kano, Kazuhisa Ikemoto, Taei Matsui, Hiroshi Ichinose, Kazunao Kondo
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Elsevier 2022-11-01
Serie:	Journal of Pharmacological Sciences
Soggetti:	Quinonoid dihydropteridine reductase Tetrahydrobiopterin Platelet aggregation Serotonin Secondary aggregation
Accesso online:	http://www.sciencedirect.com/science/article/pii/S1347861322000664
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