Cefepime and New Cefepime/Beta-Lactamase Inhibitor Combination for the Treatment of Gram-Negative Bacteria: Chemical Structure and Mechanism of Action, Microbiological Target, Clinical Use and PK/PD Characteristics

The global spread of multidrug-resistant (MDR) Gram-negative bacteria, particularly extended-spectrum β-lactamase (ESBL)- and carbapenemase-producing <i>Enterobacterales</i>, <i>Pseudomonas aeruginosa</i>, and <i>Acinetobacter baumannii</i>, presents a significant public health challenge by limiting...

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主要な著者:	Davide Carcione, Gioconda Brigante, Antonella Carducci, Jari Intra, Simone Ambretti, Floriana Campanile, Gabriele Arcari, Nicasio Mancini, Dario Cattaneo, Floriana Gona, Mariagrazia Perilli, Alessandra Piccirilli, Nicholas Geremia, Verena Zerbato, Stefano Di Bella, Giovanna Maria Nicolò, Luigi Principe
フォーマット:	Artigo
言語:	Inglês
出版事項:	MDPI AG 2026-02-01
シリーズ:	Pharmaceuticals
主題:	cefepime β-lactam/β-lactamase inhibitor (BL/BLI) combinations zidebactam taniborbactam enmetazobactam nacubactam
オンライン･アクセス:	https://www.mdpi.com/1424-8247/19/2/283
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