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Population pharmacokinetic modeling of CSF to blood clearance: prospective tracer study of 161 patients under work-up for CSF disorders

Abstract Background Quantitative measurements of cerebrospinal fluid to blood clearance has previously not been established for neurological diseases. Possibly, variability in cerebrospinal fluid clearance may affect the underlying disease process and may possibly be a source of under- or over-dosag...

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Principais autores: Markus Herberg Hovd, Espen Mariussen, Hilde Uggerud, Aslan Lashkarivand, Hege Christensen, Geir Ringstad, Per Kristian Eide
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2022-07-01
Serier:Fluids and Barriers of the CNS
Fag:
Cerebrospinal fluid
Clearance
Gadobutrol
Brain metabolites
Intrathecal administration
Intrathecal drugs
Online adgang:https://doi.org/10.1186/s12987-022-00352-w
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