Population pharmacokinetic modeling of CSF to blood clearance: prospective tracer study of 161 patients under work-up for CSF disorders

Abstract Background Quantitative measurements of cerebrospinal fluid to blood clearance has previously not been established for neurological diseases. Possibly, variability in cerebrospinal fluid clearance may affect the underlying disease process and may possibly be a source of under- or over-dosag...

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Autori principali:	Markus Herberg Hovd, Espen Mariussen, Hilde Uggerud, Aslan Lashkarivand, Hege Christensen, Geir Ringstad, Per Kristian Eide
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	BMC 2022-07-01
Serie:	Fluids and Barriers of the CNS
Soggetti:	Cerebrospinal fluid Clearance Gadobutrol Brain metabolites Intrathecal administration Intrathecal drugs
Accesso online:	https://doi.org/10.1186/s12987-022-00352-w
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