Cracking the Molecular Origin of Intrinsic Tyrosine Kinase Activity through Analysis of Pathogenic Gain-of-Function Mutations

The basal (ligand-independent) kinase activity of receptor tyrosine kinases (RTKs) promotes trans-phosphorylation on activation loop tyrosines upon ligand-induced receptor dimerization, thus upregulating intrinsic kinase activity and triggering intracellular signaling. To understand the molecular de...

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Hlavní autoři:	Huaibin Chen, Zhifeng Huang, Kaushik Dutta, Steven Blais, Thomas A. Neubert, Xiaokun Li, David Cowburn, Nathaniel J. Traaseth, Moosa Mohammadi
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Elsevier 2013-07-01
Edice:	Cell Reports
On-line přístup:	http://www.sciencedirect.com/science/article/pii/S2211124713003173
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