A dual readout embryonic zebrafish xenograft model of rhabdomyosarcoma to assess clinically relevant multi-receptor tyrosine kinase inhibitors

BackgroundRhabdomyosarcoma (RMS) is a highly aggressive soft tissue sarcoma, affecting children and adolescents, with poor prognosis in some patient groups. Better therapeutic regimens and preclinical models to test them in are needed. Multi-receptor tyrosine kinase inhibitors (MRTKIs) are licensed...

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Principais autores:	Joseph W. Wragg, Emma L. Gray, Rui Monteiro, Jo R. Morris, Andrew D. Beggs, Ferenc Müller, Susanne A. Gatz
Formato:	Artigo
Idioma:	Inglês
Publicado:	Frontiers Media S.A. 2025-05-01
Series:	Frontiers in Oncology
Assuntos:	rhabdomyosarcoma multi-receptor tyrosine kinase inhibitors (MRTKI) zebrafish xenograft VEGF FGF
Acceso en liña:	https://www.frontiersin.org/articles/10.3389/fonc.2025.1547202/full
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