Intersegment Contacts of Potentially Damaging Variants of Cardiac Sodium Channel

Over 1,500 missense variants of sodium channel hNav1.5, which are reported in the ClinVar database, are associated with cardiac diseases. For most of the variants, the clinical significance is uncertain (VUS), not provided (NP), or has conflicting interpretations of pathogenicity (CIP). Reclassifyin...

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Κύριοι συγγραφείς:	Vyacheslav S. Korkosh, Anastasia K. Zaytseva, Anna A. Kostareva, Boris S. Zhorov
Μορφή:	Artigo
Γλώσσα:	Inglês
Έκδοση:	Frontiers Media S.A. 2021-11-01
Σειρά:	Frontiers in Pharmacology
Θέματα:	Brugada syndrome cardiac arrhythmias cryo-EM structure homology modeling intersegment contacts long QT syndrome
Διαθέσιμο Online:	https://www.frontiersin.org/articles/10.3389/fphar.2021.756415/full
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