Intersegment Contacts of Potentially Damaging Variants of Cardiac Sodium Channel

Over 1,500 missense variants of sodium channel hNav1.5, which are reported in the ClinVar database, are associated with cardiac diseases. For most of the variants, the clinical significance is uncertain (VUS), not provided (NP), or has conflicting interpretations of pathogenicity (CIP). Reclassifyin...

Full beskrivning

Bibliografiska uppgifter

Huvudupphov:	Vyacheslav S. Korkosh, Anastasia K. Zaytseva, Anna A. Kostareva, Boris S. Zhorov
Materialtyp:	Artigo
Språk:	Inglês
Utgiven:	Frontiers Media S.A. 2021-11-01
Serie:	Frontiers in Pharmacology
Ämnen:	Brugada syndrome cardiac arrhythmias cryo-EM structure homology modeling intersegment contacts long QT syndrome
Länkar:	https://www.frontiersin.org/articles/10.3389/fphar.2021.756415/full
Taggar:	Lägg till en tagg Inga taggar, Lägg till första taggen!