HDL from 36-h fasted participants potently promotes efflux of cholesteryl ester from activated microglia

The potential impact of lifestyle changes such as prolonged fasting on brain health still remains unclear. Neurodegenerative diseases often exhibit two key hallmarks: accumulation of misfolded proteins such as amyloid beta oligomers (AβO) and intracellular cholesterol accumulation. In this study, we...

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Autors principals:	Joanne K. Agus, Oscar M. Muñoz Herrera, Christopher H. Rhodes, Jack Jingyuan Zheng, Chenghao Zhu, Maurice Wong, Xinyu Tang, Izumi Maezawa, Lee-Way Jin, Carlito B. Lebrilla, Danielle J. Harvey, Angela M. Zivkovic
Format:	Artigo
Idioma:	Inglês
Publicat:	Frontiers Media S.A. 2025-08-01
Col·lecció:	Frontiers in Aging Neuroscience
Matèries:	high-density lipoprotein dementia Alzheimer’s disease fasting cholesterol accumulation
Accés en línia:	https://www.frontiersin.org/articles/10.3389/fnagi.2025.1629496/full
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