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C3 glomerulopathy: a kidney disease mediated by alternative pathway deregulation

C3 glomerulopathy (C3G) is an ultra-rare complement-mediated kidney disease caused by to the deregulation of the alternative pathway (AP) of proximal complement. Consequently, all effector loops of the complement are active and can lead to pathologies, such as C3a- and C5a-mediated inflammation, C3b...

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Principais autores: Karin Heidenreich, Deepti Goel, P. S. Priyamvada, Sagar Kulkarni, Vipul Chakurkar, Dinesh Khullar, Ravi Singh, Charan Bale, Peter F. Zipfel
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2024-10-01
coleção:Frontiers in Nephrology
Assuntos:
C3 glomerulopathy
complement
therapy
complement inhibitors
alternative pathway (AP)
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fneph.2024.1460146/full
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