Metal ion transporter SLC39A14-mediated ferroptosis and glycosylation modulate the tumor immune microenvironment: pan-cancer multi-omics exploration of therapeutic potential

Abstract Background Ferroptosis, an iron-dependent form of regulated cell death driven by lipid peroxidation, has emerged as a pivotal mechanism in cancer progression and therapeutic resistance. Concurrently, glycosylation, as a key post-translational modification, plays a critical role in regulatin...

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Egile Nagusiak:	Yi-Chun Chiang, Chih-Yang Wang, Sachin Kumar, Chung-Bao Hsieh, Kai-Fu Chang, Ching-Chung Ko, Chih-Hsuan Chang, Hui-Ru Lin, Chi-Jen Wu, Chien-Han Yuan, Do Thi Minh Xuan, Juan Lorell Ngadio, Dahlak Daniel Solomon, Fitria Sari Wulandari, Hung-Yun Lin, Shun-Fa Yang, Yung-Kuo Lee
Formatua:	Artigo
Hizkuntza:	Inglês
Argitaratua:	BMC 2025-10-01
Saila:	Cancer Cell International
Gaiak:	SLC39A14 Ferroptosis Glycosylation Tumor microenvironment Immune infiltration Pan-cancer analysis
Sarrera elektronikoa:	https://doi.org/10.1186/s12935-025-04003-6
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